The artist has donated the complete sum of his £25k honor prize money to the trust for venues, which operates to preserve the UK's grassroots live music spots.
Fender was awarded the award on October 16 as his latest record People Watching was declared the top album of the last 12 months.
He has opted to hand the money over to the trust, in acknowledgment of the vital role local spots had in his beginning days.
"I personally would not have achieved my current career if it hadn't been for all the shows I performed around the region, and beyond, when I was beginning," remarked the artist. "These locations are renowned, but they are facing challenges."
Beginning in 2023, at least 150 of these spaces have permanently closed – roughly 16 percent of the whole industry in the UK.
Recently, top acts including Pulp, the group Coldplay, the singer Katy Perry and Ed Sheeran have all supported the MVT in its efforts to help venues survive, by applying a minor surcharge to their ticket costs, which supports smaller concert halls.
Sam Fender also took part, collecting over £100k on his recent tour to support thirty-eight grassroots venues across the UK.
The donation assisted locations that were facing imminent closure due to issues stemming from water damage, fires and personal losses, as well as permit problems, legal disputes and sound issues.
Some locations obtained funding support in modernizing facilities and sound and lighting systems that positively impacted performers and concertgoers.
"The idea that revenue from performances in large arenas backs the independent spots, where it kicks off for artists like me, is just sensible," Sam Fender has said.
Fender is not the first artist to give his Mercury Prize winnings to charitable organizations.
When the band received the award in the year 1996 for their album their work, lead singer the singer declared that the act would contribute their prize money to the charity War Child.
In 2002, rapper and singer Ms Dynamite split her prize across multiple charities, such as the children's charity and a charity for Sickle Cell.
"And I donated a grand to my local community centre, to their classes, because I trained in gymnastics when I was growing up and they lacked better apparatus," Ms Dynamite told outlets.
In recent years, the band contributed their prize money to the community center that developed their act, alongside other grassroots music organisations.
Also 1994 winners M People donated their award to a MS organization after a acquaintance was identified with the disease.
"The victory was quite enough," remarked vocalist Heather Small. "The money was the extra but we didn't require the extra, because we had the cake. So our victory affected another person's life."
In the past week, the trust revealed it had rescued two small stages in the South East, by transferring them to public stewardship.
One venue in the city and the other in Bristol were acquired under the community ownership scheme, which is supported by a national body and music fans who purchase "stakes" in the venues.
